Now showing items 71-74 of 74
RKIP: A key regulator in tumor metastasis initiation and resistance to apoptosis: Therapeutic targeting and impact
RAF-kinase inhibitor protein (RKIP) is a well-established tumor suppressor that is frequently downregulated in a plethora of solid and hematological malignancies. RKIP exerts antimetastatic and pro-apoptotic properties in ...
NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression
N-alpha-acetyltransferase 40 (NAA40) catalyzes the transfer of an acetyl moiety to the alpha-amino group of serine 1 (S1) on histones H4 and H2A. Our previous studies linked NAA40 and its corresponding N-terminal acetylation ...
Understanding the interplay between COX-2 and hTERT in colorectal cancer using a multi-omics analysis
Background: Cyclooxygenase 2 (COX-2) is involved in the initial steps of colorectal cancer (CRC) formation, playing a key role in the catalysis of arachidonic acid to prostaglandin E2 (PGE2). The human telomerase reverse ...
RNA editing in the forefront of epitranscriptomics and human health
Post-Transcriptional modifications have been recently expanded with the addition of RNA editing, which is predominantly mediated by adenosine and cytidine deaminases acting on DNA and RNA. Here, we review the full spectrum ...