Now showing items 1-5 of 5
Loss of imprinting and aberrant methylation of IGF2 in placentas from pregnancies complicated with fetal growth restriction
The objective of this study was to investigate the hypothesis that the altered epigenetic mechanisms that regulate IGF2 imprinting in placentas from fetal growth restricted (FGR) pregnancies affect IGF2 expression leading ...
Transcriptional regulation of TIMPs in ascending aorta aneurysms
he events that result in the establishment and progression of aortic aneurysms are complex and multifactorial. However, degradation of the extracellular matrix (ECM) of aortic tunica media appears to be a consistent ...
Genomic instability, mutations and expression analysis of the tumour suppressor genes p14<sup>ARF</sup>, p15<sup>INK4b</sup>, p16<sup>INK4a</sup>and p53 in actinic keratosis
Actinic keratosis (AK) is a well-established pre-cancerous skin lesion that has the potential to progress to squamous cell carcinoma (SCC). We investigated the involvement of the CDKN2A, CDKN2B and p53 genes in AK and in ...
Mutations and differential expression of the ras family genes in human nasal polyposis
Although it is well established that ras genes contribute to tumourigenesis either through the accumulation of mutations or by aberrant expression in a wide range of human cancers, little is known regarding their involvement ...
Expression analysis of VEGFA, FGF2, TGFβ1, EGF and IGF1 in human nasal polyposis
A better understanding of the expression profile of a group of angiogenic markers in nasal polyps (NPs) would contribute considerably to the investigation of the formation of NPs. The aim of this study was to evaluate the ...