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dc.contributor.authorAmanatidou, Virginia
dc.contributor.authorZaravinos, Apostolos
dc.contributor.authorApostolakis, Stavros Z.
dc.contributor.authorSpandidos, Demetrios A.
dc.date.accessioned2018-11-06T09:52:52Z
dc.date.available2018-11-06T09:52:52Z
dc.date.issued2011-09-12
dc.identifierSCOPUS_ID:80052426594
dc.identifier.issn10408401
dc.identifier.otherPubMed ID: 21899514
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80052426594&origin=inward
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/727
dc.description.abstractChemokines are small chemoattractant cytokines involved in cell trafficking and activation. Despite the general nonspecific nature of chemokine activity in certain instances, specific chemokine expression patterns have been associated with specific disease states. In the field of respiratory viral infection, evidence suggests that response to viral invasion is regulated by a distinct chemokine expression profile involving more CC chemokines than CXC chemokines. Moreover, among the CC chemokines, CCL3 and CCL5 appear to be most commonly implicated in viral respiratory disease. Most data available in this field have been derived from in vitro studies, as well as studies conducted in animal models with limited evidence obtained in settings of actual human disease. In the present review, we focus on the diagnostic, prognostic, and therapeutic potential of virus-induced chemokine activity as reflected by studies conducted in actual disease states, either in animal models or humans. We further discuss whether these data advocate chemokines as a realistic clinical tool for the management of viral infection.
dc.relation.ispartofCritical Reviews in Immunology
dc.titleChemokines in respiratory viral infections: Focus on their diagnostic and therapeutic potential
elsevier.identifier.eid2-s2.0-80052426594
elsevier.identifier.scopusidSCOPUS_ID:80052426594
elsevier.volume31
elsevier.issue.identifier4
elsevier.coverdate2011-09-12
elsevier.coverdisplaydate2011
elsevier.openaccess0
elsevier.openaccessflagfalse
elsevier.aggregationtypeJournal


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