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dc.contributor.authorKonstandi, Maria
dc.contributor.authorJohnson, Elizabeth O.
dc.contributor.authorLang, Matti
dc.date.accessioned2018-11-02T07:55:23Z
dc.date.available2018-11-02T07:55:23Z
dc.date.issued2014-01-01
dc.identifierSCOPUS_ID:84902270799
dc.identifier.issn01497634
dc.identifier.otherPubMed ID: 24877684
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84902270799&origin=inward
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/663
dc.description.abstractMost drugs are metabolized in the liver by cytochromes P450 (CYPs). Stress can modify CYP-catalyzed drug metabolism and subsequently, the pharmacokinetic profile of a drug. Current evidence demonstrates a gene-, stress- and species-specific interference in stress-mediated regulation of genes encoding the major drug-metabolizing CYP isozymes. Stress-induced up-regulation of CYPs that metabolize the majority of prescribed drugs can result in their increased metabolism and consequently, in failure of pharmacotherapy. In contrast, stress-induced down-regulation of CYP isozymes, including CYP2E1 and CYP2B1/2, potentially reduces metabolism of several toxicants and specific drugs-substrates resulting in increased levels and altered toxicity. The primary stress effectors, the adrenergic receptor-linked pathways and glucocorticoids, play primary and distinct roles in stress-mediated regulation of CYPs. Evidence demonstrates that stress regulates major drug metabolizing CYP isozymes, suggesting that stress should be considered to ensure pharmacotherapy efficacy and minimize drug toxicity. A detailed understanding of the molecular events underlying the stress-dependent regulation of drug metabolizing CYPs is crucial both for the design of new drugs and for physiology-based pharmacokinetic and pharmacodynamic modeling.
dc.relation.ispartofNeuroscience and Biobehavioral Reviews
dc.titleConsequences of psychophysiological stress on cytochrome P450-catalyzed drug metabolism
elsevier.identifier.doi10.1016/j.neubiorev.2014.05.011
elsevier.identifier.eid2-s2.0-84902270799
elsevier.identifier.piiS0149763414001286
elsevier.identifier.scopusidSCOPUS_ID:84902270799
elsevier.volume45
elsevier.coverdate2014-01-01
elsevier.coverdisplaydateSeptember 2014
elsevier.openaccess0
elsevier.openaccessflagfalse
elsevier.aggregationtypeJournal


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