• Login
    View Item 
    •   Plemochoe Home
    • Articles / Άρθρα
    • School of Sciences
    • Department of Life Sciences
    • View Item
    •   Plemochoe Home
    • Articles / Άρθρα
    • School of Sciences
    • Department of Life Sciences
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of PlemochoeCommunities & CollectionsTitlesAuthorsBy Issue DateSubjectsThis CollectionTitlesAuthorsBy Issue DateSubjects

    My Account

    LoginRegister

    Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: A systems biology approach

    Thumbnail
    View/Open
    Publisher version (Access full-text PDFOpen Access)
    Publisher version (Check access options)
    Check access options
    Date
    2012-05-01
    Author
    Lambrou, George I.
    Zaravinos, Apostolos
    Adamaki, Maria
    Spandidos, Demetrios A.
    Tzortzatou- Stathopoulou, Fotini
    Vlahopoulos, Spiros
    Metadata
    Show full item record
    Abstract
    A part of current research has intensively been focused on the proliferation and metabolic processes governing biological systems. Since the advent of high throughput methodologies such as microarrays, the load of genomic data has increased geometrically and along with that the need for computational methods to interpret these data. In the present study, we investigated in vitro the common proliferation and metabolic processes, associated with common oncogenic pathways, as far as gene expression is concerned, between the T-cell acute lymphoblastic leukemia (CCRF-CEM) and the rhabdomyosarcoma (TE-671) cell lines. We present a computational approach, using cDNA microarrays, in order to identify commonalities between diverse biological systems. Our analysis predicted that JAK1, STAT1, PIAS2 and CDK4 are the driving forces in the two cell lines. This type of analysis may lead to the understanding of the common mechanisms that transform physiological cells to malignant, and may reveal a new holistic approach to understanding the dynamics of tumor onset as well as the mechanistics behind oncogenic drivers.
    URI
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860282813&origin=inward
    hhttps://repo.euc.ac.cy/handle/123456789/616
    DOI
    10.3892/ijo.2012.1361
    Collections
    • Department of Life Sciences

    entitlement

    Contact us

    Tel: +357 22 713000
    Fax: +357 22 662051
    Use contact form

    Find us

    European University Cyprus
    6, Diogenis Str., Engomi,
    P.O. Box: 22006, 1516 Nicosia-Cyprus
    View location map

    Connect with us

    Send your request to us

    Request Info
     
    • Contact us
    • Find us
    • Connect with us
    • Request Info
    © 2017 European University Cyprus, All Rights Reserved