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dc.contributor.authorAyiomamitis, Georgios D.
dc.contributor.authorNotas, George
dc.contributor.authorZaravinos, Apostolos
dc.contributor.authorZizi-Sermpetzoglou, Adamantia
dc.contributor.authorGeorgiadou, Maria
dc.contributor.authorSfakianaki, Ourania
dc.contributor.authorKouroumallis, Elias
dc.date.accessioned2018-10-25T12:30:36Z
dc.date.available2018-10-25T12:30:36Z
dc.date.issued2014-01-01
dc.identifierSCOPUS_ID:84904321295
dc.identifier.issn0008428X
dc.identifier.otherPubMed ID: 24869613
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84904321295&origin=inward
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/579
dc.description.abstractBackground: Colorectal cancer is one of the most common cancers and the third leading cause of cancer death in both sexes. The disease progresses as a multistep process and is associated with genetic alterations. One of the characteristic features of cancer is telo - merase activation. We sought to evaluate the differences in telomerase activity between colon cancer and adjacent normal tissue and to correlate the differences in telomerase activity between different locations with clinicopathological factors and survival. Methods: Matched colon tumour samples and adjacent normal mucosa samples 10 cm away from the tumour were collected during colectomy. We assessed telomerase activity using real time polymerase chain reaction. Several pathological characteristics of tumours, including p53, Ki-67, p21, bcl2 and MLH1 expression were also studied. Results: We collected samples from 49 patients. There was a significantly higher telomerase activity in colon cancer tissue than normal tissue. Adenocarcinomas of the right colon express significantly higher telomerase than left-side cancers. Colon cancers and their adjacent normal tissue had significantly more telomerase and were more positive to MLH1 than rectal cancers. The expression of p53 negatively correlated to telomerase activity and was linked to better patient survival. Conclusion: Colon and rectal cancers seem to have different telomerase and MLH1 profiles, and this could be another factor for their different biologic and clinical behaviour and progression. These results support the idea that the large bowel cannot be considered a uniform organ, at least in the biology of cancer.
dc.relation.ispartofCanadian Journal of Surgery
dc.titleDifferences in telomerase activity between colon and rectal cancer
elsevier.identifier.doi10.1503/cjs.031312
elsevier.identifier.eid2-s2.0-84904321295
elsevier.identifier.piiS0008428X14500677
elsevier.identifier.scopusidSCOPUS_ID:84904321295
elsevier.volume57
elsevier.issue.identifier3
elsevier.coverdate2014-01-01
elsevier.coverdisplaydateJune 2014
elsevier.openaccess1
elsevier.openaccessflagtrue
elsevier.aggregationtypeJournal


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