Show simple item record

dc.contributor.authorTzanetakou, Irene
dc.contributor.authorKatsilambros, Nicholaos L.
dc.contributor.authorBénétos, Athanase M.
dc.contributor.authorMikhailidis, Dimitri P.
dc.contributor.authorPerrea, Despina N.
dc.date.accessioned2018-10-23T09:51:04Z
dc.date.available2018-10-23T09:51:04Z
dc.date.issued2012-04-01
dc.identifierSCOPUS_ID:84855161230
dc.identifier.issn15681637
dc.identifier.otherPubMed ID: 22186032
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84855161230&origin=inward
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/531
dc.description.abstractObesity is a condition in which excess or abnormal fat accumulation may present with adverse effects on health and decreased life expectancy. Increased body weight and adipose tissue accumulation amplifies the risk of developing various age-related diseases, such as cardiovascular disease, Type 2 Diabetes Mellitus, musculoskeletal disorders, respiratory diseases and certain types of cancer. This imbalance in body composition and body weight is now recognized as a state of increased oxidative stress and inflammation for the organism.Increasing oxidative stress and inflammation affect telomeres. Telomeres are specialized DNA-protein structures found at the ends of eukaryotic chromosomes and serve as markers of biological aging rate. They also play a critical role in maintaining genomic integrity and are involved in age-related metabolic dysfunction. Erosion of telomeres is hazardous to healthy cells, as it is a known mechanism of premature cellular senescence and loss of longevity. The association of telomeres and oxidative stress is evident in cultured somatic cells in vitro, where oxidative stress enhances the process of erosion with each cycle of replication.Shorter telomeres have been associated with increasing body mass index, increased adiposity, and more recently with increasing waist to hip ratio and visceral excess fat accumulation. Furthermore, many of the metabolic imbalances of obesity (e.g. glycemic, lipidemic, etc.) give rise to organ dysfunction in a way that resembles the accelerated aging process.This article is a non-systematic review of the evidence linking obesity and accelerated aging processes as they are regulated by telomeres.
dc.relation.ispartofAgeing Research Reviews
dc.title" Is obesity linked to aging?". Adipose tissue and the role of telomeres.
elsevier.identifier.doi10.1016/j.arr.2011.12.003
elsevier.identifier.eid2-s2.0-84855161230
elsevier.identifier.piiS1568163711000754
elsevier.identifier.scopusidSCOPUS_ID:84855161230
elsevier.volume11
elsevier.issue.identifier2
elsevier.coverdate2012-04-01
elsevier.coverdisplaydateApril 2012
elsevier.openaccess0
elsevier.openaccessflagfalse
elsevier.aggregationtypeJournal


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record