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dc.contributor.authorKorou, Laskarina Maria A.
dc.contributor.authorDoulamis, Ilias P.
dc.contributor.authorTzanetakou, Irene
dc.contributor.authorMikhailidis, Dimitri P.
dc.contributor.authorPerrea, Despina N.
dc.date.accessioned2018-10-23T08:14:38Z
dc.date.available2018-10-23T08:14:38Z
dc.date.issued2013-12-17
dc.identifierSCOPUS_ID:84890246258
dc.identifier.issn00236772
dc.identifier.otherPubMed ID: 23760563
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84890246258&origin=inward
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/523
dc.description.abstractMice are widely used in studies investigating the effect of diet on metabolic risk factors, such as lipid profiles and plasma glucose levels. An important factor that is usually not taken into account is the biological age of the experimental models. The up-to-date identified experimental confounders do not cover all the parameters that may affect the results of animal studies. The aim of this study was to investigate the effects of a high-fat diet on the metabolic profile, hepatic and renal function in mice of differing ages. For this purpose two groups of male C57BL/6J mice were used, consisting of 10-week-old mice and 54-week-old mice in each group. Both groups followed identical high-fat diets for 12 weeks. The younger mice showed smaller increases in body weight, serum total cholesterol, glucose and urea levels while they had higher increases in high-density lipoprotein cholesterol levels than the older mice. Our results indicate the necessity to consider an experimental animal's age as a confounding factor when researching or interpreting metabolic studies. Age adjustment is warranted in all animal research while a uniform approach regarding the age of the animal models should be applied in experimental studies.
dc.relation.ispartofLaboratory Animals
dc.titleThe effect of biological age on the metabolic responsiveness of mice fed a high-fat diet
elsevier.identifier.doi10.1177/0023677213480768
elsevier.identifier.eid2-s2.0-84890246258
elsevier.identifier.scopusidSCOPUS_ID:84890246258
elsevier.volume47
elsevier.issue.identifier4
elsevier.coverdate2013-12-17
elsevier.coverdisplaydate2013
elsevier.openaccess0
elsevier.openaccessflagfalse
elsevier.aggregationtypeJournal


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