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dc.contributor.authorKonstantopoulos, Kostas
dc.contributor.authorZamba-Papanicolaou, Eleni
dc.contributor.authorChristodoulou, Kyproula
dc.creatorKonstantopoulos, Kostas
dc.date.accessioned2018-10-09T13:09:06Z
dc.date.available2018-10-09T13:09:06Z
dc.date.issued2018-09-01
dc.identifierSCOPUS_ID:85047422399
dc.identifier.issn15901874
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047422399&origin=inward
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/388
dc.description.abstractBackground: Dysarthrophonia is often reported by hereditary spastic paraplegia (HSP) patients with SPG11 mutations but it has been poorly investigated. Objective: The goal of this study was to investigate dysarthrophonia in SPG11 patients using quantitative measures. The voice/speech of two patients and a non-affected mutation carrier was recorded and analyzed using electroglottography (EGG) and speech acoustics. Results: Dysarthrophonia showed a higher standard deviation of the average fundamental frequency, a three to eight times higher jitter, a 80–110 Hz higher mean fundamental frequency, and a two times higher fundamental frequency range. Diadochokinesis showed a pattern of a two to three times increase in the mean duration of the release burst of the phonemes /p/, /t/, /k/ as well as a 1.5 time increase in the mean vowel duration of the syllables /pa/, /ta/, /ka/. Conclusion: Non-invasive physiological methods (EGG and speech acoustics) offer essential tools for the assessment of dysarthrophonia in SPG11 patients.
dc.relation.ispartofNeurological Sciences
dc.titleQuantification of dysarthrοphonia in a Cypriot family with autosomal recessive hereditary spastic paraplegia associated with a homozygous SPG11 mutation
elsevier.identifier.doi10.1007/s10072-018-3453-8
elsevier.identifier.eid2-s2.0-85047422399
elsevier.identifier.scopusidSCOPUS_ID:85047422399
elsevier.volume39
elsevier.issue.identifier9
elsevier.coverdate2018-09-01
elsevier.coverdisplaydate1 September 2018
elsevier.openaccess0
elsevier.openaccessflagfalse
elsevier.aggregationtypeJournal


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