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dc.contributor.authorNiforopoulou, Panagiota
dc.contributor.authorIacovidou, Nicoletta
dc.contributor.authorLelovas, Pavlos
dc.contributor.authorKarlis, George
dc.contributor.authorPapalois, Apostolos E.
dc.contributor.authorSiakavellas, Spyros
dc.contributor.authorSpapis, Vasileios
dc.contributor.authorKaparos, George
dc.contributor.authorSiafaka, Ioanna
dc.contributor.authorXanthos, Theodoros
dc.creatorNiforopoulou, Panagiota
dc.date.accessioned2018-10-03T13:07:15Z
dc.date.available2018-10-03T13:07:15Z
dc.date.issued2017-06-01
dc.identifierDOI:10.1016/j.ajem.2017.01.040
dc.identifier.issn07356757
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0735675717300578
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/356
dc.description.abstractPurposeTo assess whether use of Impedance Threshold Device (ITD) during cardiopulmonary resuscitation (CPR) reduces the degree of post-cardiac arrest Acute Kidney Injury (AKI), as a result of improved hemodynamics, in a porcine model of ventricular fibrillation (VF) cardiac arrest. MethodsAfter 8 min of untreated cardiac arrest, the animals were resuscitated either with active compression-decompression (ACD) CPR plus a sham ITD (control group, n=8) or with ACD-CPR plus an active ITD (ITD group, n=8). Adrenaline was administered every 4 min and electrical defibrillation was attempted every 2 min until return of spontaneous circulation (ROSC) or asystole. After ROSC the animals were monitored for 6 h under general anesthesia and then returned to their cages for a 48 h observation, before euthanasia. Two novel biomarkers, Neutrophil Gelatinase-Associated Lipocalin (NGAL) in plasma and Interleukin-18 (IL-18) in urine, were measured at 2 h, 4 h, 6 h, 24 h and 48 h post-ROSC, in order to assess the degree of AKI. ResultsROSC was observed in 7 (87.5%) animals treated with the sham valve and 8 (100%) animals treated with the active valve (P=NS). However, more than twice as many animals survived at 48 h in the ITD group (n=8, 100%) compared to the control group (n=3, 37.5%). Urine IL-18 and plasma NGAL levels were augmented post-ROSC in both groups, but they were significantly higher in the control group compared with the ITD group, at all measured time points. ConclusionUse of ITD during ACD-CPR improved hemodynamic parameters, increased 48 h survival and decreased the degree of post-cardiac arrest AKI in the resuscitated animals.
dc.relation.ispartofThe American Journal of Emergency Medicine
dc.subjectCardiopulmonary resuscitation
dc.subjectVentricular fibrillation
dc.subjectImpedance Threshold Device
dc.subjectAcute Kidney Injury
dc.subjectNeutrophil Gelatinase-Associated Lipocalin
dc.subjectInterleukin-18
dc.titleCorrelation of Impedance Threshold Device use during cardiopulmonary resuscitation with post-cardiac arrest Acute Kidney Injury
dc.typeOriginal Contribution
dc.rights.license© 2017 Elsevier Inc. All rights reserved.
elsevier.identifier.doi10.1016/j.ajem.2017.01.040
elsevier.identifier.eid1-s2.0-S0735675717300578
elsevier.identifier.piiS0735-6757(17)30057-8
elsevier.identifier.scopusid85010903966
elsevier.identifier.pubmedid28131602
elsevier.volume35
elsevier.issue.identifier6
elsevier.coverdate2017-06-01
elsevier.coverdisplaydateJune 2017
elsevier.startingpage846
elsevier.endingpage854
elsevier.openaccess0
elsevier.openaccessarticlefalse
elsevier.openarchivearticlefalse
elsevier.teaserTo assess whether use of Impedance Threshold Device (ITD) during cardiopulmonary resuscitation (CPR) reduces the degree of post-cardiac arrest Acute Kidney Injury (AKI), as a result of improved hemodynamics,...
elsevier.aggregationtypeJournal


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