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dc.contributor.authorChalkias, Athanasios
dc.contributor.authorXanthos, Theodoros
dc.contributor.authorPapageorgiou, Effie
dc.contributor.authorAnania, Artemis
dc.contributor.authorBeloukas, Apostolos
dc.contributor.authorPavlopoulos, Fotios
dc.creatorChalkias, Athanasios
dc.date.accessioned2018-10-03T10:24:55Z
dc.date.available2018-10-03T10:24:55Z
dc.date.issued2018-08-07
dc.identifierDOI:10.1016/j.hrtlng.2018.06.011
dc.identifier.issn01479563
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0147956318301171
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/347
dc.description.abstractPurposeTo assess the intraoperative initiation and feasibility of a modified NIH-NHLBI ARDS Network Mechanical Ventilation Protocol (mARDSNet protocol) in septic patients with severe ARDS. Materials and methodsThis prospective observational study included consecutive adult septic patients with severe ARDS who underwent emergency abdominal surgery prior to intensive care unit (ICU) admission. The primary outcome was survival to hospital discharge and at 90 days. Secondary outcomes were intraoperative adverse events and ICU length of stay. ResultsSeven patients were included. A statistically significant difference in lung compliance [ε=0.150, F(1.053, 3.158)=31.098, p=0.010] and driving pressure [ε=0.263, F(1.844, 5.532)=7.042, p=0.031] was observed with time, while plateau pressure did not changed significantly during surgery [ε=0.322, F(2.256, 6.769)=1.920, p=0.219]. Also, PEEP values were constantly increased during surgery [ε=0.252, F(1.766, 5.297)=9.994, p=0.017], with the highest values being observed towards to the end of the procedure. No intraoperative adverse events were observed. Mean (±SD) ICU length of stay was 10.43 (±2.64) days, while all patients survived to hospital discharge and at 90 days. ConclusionsThe intraoperative implementation of our mARDSNet protocol is feasible and may increase the survival of septic patients with severe ARDS if initiated prior to ICU admission.
dc.relation.ispartofHeart & Lung
dc.subjectSepsis
dc.subjectAcute respiratory distress syndrome
dc.subjectAcute care anesthesiology
dc.subjectEmergency surgery
dc.subjectARDSNet protocol
dc.subjectOutcome
dc.titleIntraoperative initiation of a modified ARDSNet protocol increases survival of septic patients with severe acute respiratory distress syndrome
dc.rights.license© 2018 Elsevier Inc. All rights reserved.
elsevier.identifier.doi10.1016/j.hrtlng.2018.06.011
elsevier.identifier.eid1-s2.0-S0147956318301171
elsevier.identifier.piiS0147-9563(18)30117-1
elsevier.identifier.scopusid85051033926
elsevier.coverdate2018-08-07
elsevier.coverdisplaydateAvailable online 7 August 2018
elsevier.openaccess0
elsevier.openaccessarticlefalse
elsevier.openarchivearticlefalse
elsevier.teaserTo assess the intraoperative initiation and feasibility of a modified NIH-NHLBI ARDS Network Mechanical Ventilation Protocol (mARDSNet protocol) in septic patients with severe ARDS....
elsevier.aggregationtypeJournal


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