Now showing items 1-6 of 6
Consequences of psychophysiological stress on cytochrome P450-catalyzed drug metabolism
Most drugs are metabolized in the liver by cytochromes P450 (CYPs). Stress can modify CYP-catalyzed drug metabolism and subsequently, the pharmacokinetic profile of a drug. Current evidence demonstrates a gene-, stress- ...
Effects of short- and long-duration hypothyroidism on function of the rat hypothalamic-pituitary-adrenal axis
The effects of hypothyroidism on the functional integrity of the hypothalamic-pituitary-adrenal (HPA) axis were investigated in adult male rats. HPA axis function was examined in vivo in sham-thyroidectomized male ...
Effects of experimentally induced hyperthyroidism on central hypothalamic-pituitary-adrenal axis function in rats: In vitro and in situ studies
Hyperthyroidism is associated with hypercorticosteronemia, although the locus that is principally responsible for the hypercorticosteronism remains unclear. The purpose of this study was to assess the effects of hyperthyroidism ...
Effects of short- and long-duration hypothyroidism on hypothalamic- pituitary-adrenal axis function in rats: In vitro and in situ studies
The purpose of this study is to assess the effects of hypothyroidism on the hypothalamic-pituitary-adrenal (HPA) axis; the functional integrity of each component of the HPA axis was examined in short-term and long-term ...
The plasma coagulation cascade: Potential targets for novel anticoagulants in major lower limb surgery
Strategies for prevention of venous thromboembolism in orthopaedic patients undergoing major lower limb surgery include pharmacological prophylaxis. Over the last three decades, the search for new safe and effective ...