Now showing items 1-5 of 5
Recovery of the rat hypothalamic-pituitary-adrenal axis after discontinuation of prolonged treatment with the synthetic glucocorticoid agonist dexamethasone
To evaluate the recovery of the hypothalamicpituitary- adrenal (HPA) axis after discontinuation of prolonged exposure to glucocorticoids, we employed adult male Sprague- Dawley rats which were implanted sc with osmotic ...
Interactions between tumor necrosis factor-α, hypothalamic corticotropin-releasing hormone, and adrenocorticotropin secretion in the rat
We studied the effects of tumor necrosis factor-α (TNFα), a macrophage-derived pleiotropic cytokine produced during the inflammatory/immune response, on the function of the hypothalamic-pituitary-adrenal (HPA) axis of the ...
‘Peripheral’ Benzodiazepine Receptor Ligands Stimulate Prolactin Release in the Rat
High concentrations of ‘peripheral’ benzodiazepine binding sites have been described in the pituitary gland and in several other endocrine glands, such as the adrenal glands and the testes. The role played by these receptors ...
Effects of peripheral benzodiazepine receptor ligands on hypothalamic-pituitary-adrenal axis function in the rat
High concentrations of the 'peripheral' benzodiazepine (pBZD) binding site ('receptor') have been described in the hypothalamus, the pituitary and the adrenal glands. This study was undertaken to examine the effects of ...
Glucocorticoids inhibit estradiol-mediated uterine growth: Possible role of the uterine estradiol receptor
Stress-related activation of the hypothalamic-pituitary-adrenal axis (HPA) is associated with suppression of the reproductive axis. This effect has been explained by findings indicating that corticotropin-releasing hormone ...