Now showing items 1-12 of 12

    • 1H NMR-metabolomics: Can they be a useful tool in our understanding of cardiac arrest? 

      Chalkias, Athanasios F.; Fanos, Vassilios Vassilios; Noto, Antonio; Castrén, Maaret Kaarina; Gulati, Anil Kumar; Svavarsdóttir, Hildigunnur; Iacovidou, Nicoletta; Xanthos, Theodoros (2014-01-01)
      Objective: This review focuses on the presentation of the emerging technology of metabolomics, a promising tool for the detection of identifying the unrevealed biological pathways that lead to cardiac arrest. Data sources: ...
    • A metabolomic approach in an experimental model of hypoxia-reoxygenation in newborn piglets: Urine predicts outcome 

      Atzori, Luigi; Xanthos, Theodoros; Barberini, Luigi; Antonucci, Roberto; Murgia, Federica; Lussu, Michele; Aroni, Filippia; Varsami, Marianna; Papalois, Αpostolos E.; Laï, Adolfo; d’Aloja, Ernesto; Iacovidou, Nicoletta; Fanos, Vassilios Vassilios (2010-10-01)
      Perinatal asphyxia is one of the leading causes of morbidity and mortality in the neonatal period. Response to oxygen treatment is unpredictable and the optimum concentration of oxygen in neonatal resuscitation is still a ...
    • An experimental model of neonatal normocapnic hypoxia and resuscitation in Landrace/Large White piglets 

      Aroni, Filippia; Xanthos, Theodoros; Varsami, Marianna; Argyri, Ioanna; Alexaki, Avgoustina; Stroumpoulis, K.; Lelovas, Pavlos P.; Papalois, Αpostolos E.; Faá, Gavino; Fanos, Vassilios Vassilios; Iacovidou, Nicoletta (2012-09-01)
      Objective: The aim of this study is to describe and evaluate an experimental model of neonatal normocapnic hypoxia and resuscitation. Methods: Ten male Landrace/Large White neonatal piglets were studied. Following anaesthesia ...
    • Hypoxia-induced endothelial damage and microthrombosis in myocardial vessels of newborn landrace/large white piglets 

      Faa, Armando; Xanthos, Theodoros; Fanos, Vassilios Vassilios; Fanni, Daniela; Gerosa, Clara; Pampaloni, Pietro; Pais, Maria Elena; Faá, Gavino; Iacovidou, Nicoletta (2014-01-01)
      Objective. Evaluating the presence of endothelial changes in myocardial vessels in an experimental model of hypoxia and resuscitation in newborn piglets. Methods. Fifty male Landrace/Large White neonatal piglets were ...
    • Hypoxia/reoxygenation-induced myocardial lesions in newborn piglets are related to interindividual variability and not to oxygen concentration 

      Faa, Armando; Iacovidou, Nicoletta; Xanthos, Theodoros; Locci, Annalisa; Pampaloni, Pietro; Aroni, Filippia; Papalois, Αpostolos E.; Faá, Gavino; Fanos, Vassilios Vassilios (2012-07-25)
      OBJECTIVE: Evaluation of myocardial histological changes in an experimental animal model of neonatal hypoxiareoxygenation. METHODS: Normocapnic hypoxia was induced in 40 male Landrace/Large White piglets. Reoxygenation was ...
    • Metabolomics applied in neonatology 

      Iacovidou, Nicoletta; Syggelou, Angeliki; Chalkias, Athanasios F.; Atzori, Luigi; Xanthos, Theodoros; Fanos, Vassilios Vassilios (2014-02-01)
      Over the past two decades, host-response biomarkers have been extensively used by clinicians for a better understanding of normal biological processes, the complexity and severity of illnesses, or pharmacological responses ...
    • Metabolomics in the Developing Human Being 

      Syggelou, Angeliki; Iacovidou, Nicoletta; Atzori, Luigi; Xanthos, Theodoros; Fanos, Vassilios Vassilios (2012-10-01)
      Metabolomics is based on the detailed analysis of metabolites and represents a unique chemical fingerprint of an organism. This approach allows assessing the dynamic behavior of biologic systems with multiple network ...
    • Metabolomics network characterization of resuscitation after normocapnic hypoxia in a newborn piglet model supports the hypothesis that room air is better 

      Fanos, Vassilios Vassilios; Noto, Antonio; Xanthos, Theodoros; Lussu, Michele; Murgia, Federica; Barberini, Luigi; Finco, Gabriele; d’Aloja, Ernesto; Papalois, Αpostolos E.; Iacovidou, Nicoletta; Atzori, Luigi (2014-01-01)
      Perinatal asphyxia is attributed to hypoxia and/or ischemia around the time of birth and may lead to multiorgan dysfunction. Aim of this research article is to investigate whether different metabolomic profiles occurred ...
    • Reoxygenation of asphyxiated newborn piglets: Administration of 100% oxygen causes significantly higher apoptosis in cortical neurons, as compared to 21% 

      Faá, Gavino; Fanos, Vassilios Vassilios; Fanni, Daniela; Gerosa, Clara; Faa, Armando; Fraschini, Matteo; Pais, Maria Elena; Di Felice, Eliana; Papalois, Αpostolos E.; Varsami, Marianna; Xanthos, Theodoros; Iacovidou, Nicoletta (2014-01-01)
      Objective. Evaluation of neuronal changes in an animal experimental model of normocapnic hypoxia- reoxygenation. Materials and Methods. Fifty male piglets were the study subjects; normocapnic hypoxia was induced in 40 ...
    • The role of novel biomarkers in early diagnosis and prognosis of acute kidney injury in newborns 

      Argyri, Ioanna; Xanthos, Theodoros; Varsami, Marianna; Aroni, Filippia; Papalois, Αpostolos E.; Dontas, Ismene A.; Fanos, Vassilios Vassilios; Iacovidou, Nicoletta (2013-01-01)
      Acute kidney injury (AKI) refers to the rapid loss of renal function. In clinical practice, AKI is common among hospitalized patients of all age groups including neonates and remains an important cause of morbidity and ...
    • The use of sildenafil in the treatment of persistent pulmonary hypertension of the newborn: A review of the literature 

      Iacovidou, Nicoletta; Syggelou, Angeliki; Fanos, Vassilios Vassilios; Xanthos, Theodoros (2012-01-01)
      Persistent pulmonary hypertension of the newborn (PPHN) is a serious and potentially fatal condition, characterized by hypoxemia due to increased pulmonary vascular resistance (PVR) with resultant shunting of pulmonary ...
    • Toward nephrogenesis in the pig kidney: The composite tubulo-glomerular nodule 

      Gerosa, Clara; Fanos, Vassilios Vassilios; Fanni, Daniela; Nemolato, Sonia; Locci, Annalisa; Xanthos, Theodoros; Papalois, Αpostolos E.; Faá, Gavino; Iacovidou, Nicoletta (2011-01-01)
      Background: Significant differences regarding nephrogenesis and its completion among different animal species have been reported. Since many informations on clinical conditions (i.e. asphyxia, drugs) are extrapolated from ...