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dc.contributor.authorSchrier, Lenneke
dc.contributor.authorHadjipanayis, Adamos
dc.contributor.authorStiris, Tom Arne
dc.contributor.authorRoss-Russell, Robert I.
dc.contributor.authorValiulis, Arũnas
dc.contributor.authorTurner, Mark A.
dc.contributor.authorZhao, Wei
dc.contributor.authorde Cock, Pieter A.J.G.
dc.contributor.authorde Wildt, Saskia N.
dc.contributor.authorAllegaert, Karel M.
dc.contributor.authorvan den Anker, John N.
dc.creatorSchrier, Lenneke
dc.date.accessioned2020-01-21T09:51:47Z
dc.date.available2020-01-21T09:51:47Z
dc.date.issued2020-01-01
dc.identifierSCOPUS_ID:85077615528
dc.identifier.issn03406199
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/2175
dc.description.abstractHealth-care professionals who prescribe medicines have the professional duty to choose medicines that are in the best interest of their individual patient, irrespective if that patient is an adult or a child. However, the availability of medicines with an appropriate label for pediatric use is lagging behind those for adults, and even available pediatric drugs are sometimes not suitable to administer to children. Consequently, health-care professionals often have no other option than to prescribe off-label medicines to children. An important reason for use of off-label medicines is to improve access to (innovative) treatments or to address medical needs and preferences of patients, especially when no other options are available. However, off-label use of medicines is in general not supported by the same level of evidence as medicines licensed for pediatric use. This may result in increased uncertainty on efficacy as well as the risk for toxicity and other side effects. In addition, liability may also be of concern, counterbalanced by professional guidelines. Conclusion: The purpose of this joint EAP/ESDPPP policy statement is to offer guidance for HCPs on when and how to prescribe off-label medicines to children and to provide recommendations for future European policy.
dc.relation.ispartofEuropean Journal of Pediatrics
dc.titleOff-label use of medicines in neonates, infants, children, and adolescents: a joint policy statement by the European Academy of Paediatrics and the European society for Developmental Perinatal and Pediatric Pharmacology
elsevier.identifier.doi10.1007/s00431-019-03556-9
elsevier.identifier.eid2-s2.0-85077615528
elsevier.identifier.scopusidSCOPUS_ID:85077615528
elsevier.coverdate2020-01-01
elsevier.coverdisplaydate2020
elsevier.openaccess0
elsevier.openaccessflagfalse
elsevier.aggregationtypeJournal


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