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dc.contributor.authorKalogirou, Andreas S.
dc.contributor.authorKoutentis, Panayiotis A.
dc.creatorKalogirou, Andreas S.
dc.date.accessioned2019-11-11T10:06:50Z
dc.date.available2019-11-11T10:06:50Z
dc.date.issued2019-12-01
dc.identifierSCOPUS_ID:85074147096
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074147096&origin=inward
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/2139
dc.description.abstract4,6-Dichloro-2-(methylthio)pyrimidine (7) was converted to 4-chloro-6-methoxy-2- (methylthio)pyrimidine (15) and 4,6-dimethoxy-2-(methylthio)pyrimidine (14). Chlorination of the latter with N-chlorosuccinimide (NCS) affords 5-chloro-4,6-dimethoxy-2-(methylthio)pyrimidine (16) in 56% yield. Both methylthiopyrimidines 15 and 14 were converted in two steps to 4-chloro-6- methoxypyrimidine-2-carbonitrile (13) and 4,6-dimethoxypyrimidine-2-carbonitrile (12), respectively, after oxidation to sulfones and displacement of the sulfinate group with KCN. 4,6- Dimethoxypyrimidine-2-carbonitrile (12) was chlorinated with NCS to give 5-chloro-4,6- dimethoxypyrimidine-2-carbonitrile (10) in 53% yield. All new compounds were fully characterized.
dc.relation.ispartofMolBank
dc.titleSynthesis of 2-cyanopyrimidines
elsevier.identifier.doi10.3390/M1086
elsevier.identifier.eid2-s2.0-85074147096
elsevier.identifier.scopusidSCOPUS_ID:85074147096
elsevier.volume2019
elsevier.issue.identifier4
elsevier.coverdate2019-12-01
elsevier.coverdisplaydateDecember 2019
elsevier.openaccess1
elsevier.openaccessflagtrue
elsevier.aggregationtypeJournal


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