Reactions of polychlorinated pyrimidines wireactions of polychlorinated pyrimidines with dabco dabco
Kalogirou, Andreas S.
Koutentis, Panayiotis A.
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The reaction of 2,4,5,6-tetrachloropyrimidine (4) and 4,5,6-trichloropyrimidine-2- carbonitrile (1) with DABCO (1 equiv.), in MeCN, at ca. 20 _C gives 2,4,5-trichloro-6-[4-(2-chloroethyl) piperazin-1-yl]pyrimidine (5) and 4,5-dichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine-2- carbonitrile (6) in 42% and 52% yields, respectively. The new compounds were fully characterized.