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dc.contributor.authorKalogirou, Andreas S.
dc.contributor.authorKourtellaris, Andreas
dc.contributor.authorKoutentis, Panayiotis A.
dc.creatorKalogirou, Andreas S.
dc.date.accessioned2019-06-26T08:51:45Z
dc.date.available2019-06-26T08:51:45Z
dc.date.issued2019-01-01
dc.identifierSCOPUS_ID:85067413227
dc.identifier.issn1434193X
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067413227&origin=inward
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/2130
dc.description.abstractA three-step synthesis of 3′,5′-dichloro-1H-spiro(quinazo-line-2,4′-[1,2,6]thiadiazin)-4(3H)-ones starting from 3,4,4,5-tetra-chloro-4H-1,2,6-thiadiazine is presented. The latter reacts with 2-aminobenzonitriles to give 2-[(3,5-dichloro-4H-1,2,6-thiadiazin-4-ylid-ene)amino]benzonitriles, which affords, after hydration, the respective benzamides. Upon heating at reflux in EtOH or HFIP, the benzamides intramolecularly cyclize onto the thiadiazine C4 position to give 3′,5′-dichloro-1H-spiro(quinazoline-2,4′-[1,2,6]thiadiazin)-4(3H)-ones. Single crystal X-ray crystallography supports the structure of two analogues. The chloride displacement of these new spiroquinazolinones was demonstrated by Stille coupling, and by reaction with methoxide to afford both the mono and bis-methoxy derivatives.
dc.relation.ispartofEuropean Journal of Organic Chemistry
dc.titleSynthesis and Reactivity of 3′,5′-Dichloro-1H-spiro(quinazoline-2,4′-[1,2,6]thiadiazin)-4(3H)-ones
elsevier.identifier.doi10.1002/ejoc.201900576
elsevier.identifier.eid2-s2.0-85067413227
elsevier.identifier.scopusidSCOPUS_ID:85067413227
elsevier.coverdate2019-01-01
elsevier.coverdisplaydate2019
elsevier.openaccess0
elsevier.openaccessflagfalse
elsevier.aggregationtypeJournal


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