The NAD+ precursor nicotinamide riboside decreases exercise performance in rats
Kourtzidis, Ioannis A.
Stoupas, Andreas T.
Gioris, Ioannis S.
Veskoukis, Aristidis S.
Margaritelis, Nikos V.
Tsantarliotou, Maria P.
Taitzoglou, Ioannis A.
Vrabas, Ioannis S.
Nikolaidis, Michalis G.
MetadataShow full item record
Background: Nicotinamide adenine dinucleotide (NAD+) and its phosphorylated form (NADP+) are key molecules in ubiquitous bioenergetic and cellular signaling pathways, regulating cellular metabolism and homeostasis. Thus, supplementation with NAD+ and NADP+ precursors emerged as a promising strategy to gain many and multifaceted health benefits. In this proof-of-concept study, we sought to investigate whether chronic nicotinamide riboside administration (an NAD+ precursor) affects exercise performance. Methods: Eighteen Wistar rats were equally divided in two groups that received either saline vehicle or nicotinamide riboside at a dose of 300 mg/kg body weight/day for 21 days via gavage. At the end of the 21-day administration protocol, both groups performed an incremental swimming performance test. Results: The nicotinamide riboside group showed a tendency towards worse physical performance by 35 % compared to the control group at the final 10 % load (94 ± 53 s for the nicotinamide riboside group and 145 ± 59 s for the control group; P = 0.071). Conclusion: Our results do not confirm the previously reported ergogenic effect of nicotinamide riboside. The potentially negative effect of nicotinamide riboside administration on physical performance may be attributed to the pleiotropic metabolic and redox properties of NAD+ and NADP+.
Showing items related by title, author, creator and subject.
Physiological and performance adaptations of elite Greco-Roman wrestlers during a one-day tournament Barbas, Ioannis; Fatouros, Ioannis; Douroudos, Ioannis I.; Chatzinikolaou, Athanasios; Michailidis, Yiannis; Draganidis, Dimitrios; Jamurtas, Ath; Nikolaidis, Michalis G.; Parotsidis, Charalambos; Theodorou, Anastasios A.; Katrabasas, Ioannis; Margonis, Konstantinos; Papassotiriou, Ioannis G.; Taxildaris, Kyriakos (2011-07-01)The aim of this study was to determine the effects of a simulated one-day Greco-Roman wrestling tournament on selected performance and inflammatory status indices. Twelve competitive wrestlers (22.1 ± 1.3 years) completed ...
Correlation between mesenteric fat thickness and serum apolipoproteins in patients with peripheral arterial occlusive disease Perelas, Apostolos I.; Safarika, Vanessa; Vlachos, Ioannis S.; Tzanetakou, Irene; Korou, Laskarina Maria A.; Konstantopoulos, Panagiotis S.; Doulamis, Ilias P.; Ioannidis, Ioannis; Kornezos, Ioannis; Gargas, Dimitrios; Klonaris, Chris N.; Perrea, Despina N.; Chatziioannou, Achilles N. (2012-10-04)Background: Visceral fat possesses the most detrimental potential for cardiovascular morbidity through the release of adipokines, as well as metabolic and proinflammatory mediators, which adversely affect metabolic and ...
Chaveles, Ioannis G.; Zaravinos, Apostolos; Habeos, Ioannis G.; Karavias, Dimitrios; Maroulis, Ioannis C.; Spandidos, Demetrios A.; Karavias, Dionissios (2012-05-01)Liver is uniquely capable to repair itself after injury. Multiple molecular and biochemical processes initiated after partial hepatectomy, lead to proliferation of all cells within the liver. MicroRNAs (miRNAs) are a class ...