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dc.contributor.authorKostaki, Evangelia
dc.contributor.authorKaramitros, Timokratis
dc.contributor.authorStefanou, Garyfallia
dc.contributor.authorMamais, Ioannis A.
dc.contributor.authorAngelis, Konstantinos
dc.contributor.authorHatzakis, Angelos E.
dc.contributor.authorKramvis, Anna
dc.contributor.authorParaskevis, Dimitrios
dc.creatorKostaki, Evangelia
dc.date.accessioned2019-03-26T11:35:17Z
dc.date.available2019-03-26T11:35:17Z
dc.date.issued2018-08-07
dc.identifierSCOPUS_ID:85053917492
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85053917492&origin=inward
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/2026
dc.description.abstractHepatitis B virus (HBV) infection constitutes a global public health problem. In order to establish how HBV was disseminated across different geographic regions, we estimated the levels of regional clustering for genotypes D and A. We used 916 HBV-D and 493 HBV-A full-length sequences to reconstruct their global phylogeny. Phylogeographic analysis was conducted by the reconstruction of ancestral states using the criterion of parsimony. The putative origin of genotype D was in North Africa/Middle East. HBV-D sequences form low levels of regional clustering for the Middle East and Southern Europe. In contrast, HBV-A sequences form two major clusters, the first including sequences mostly from sub-Saharan Africa, and the second including sequences mostly from Western and Central Europe. Conclusion: We observed considerable differences in the global dissemination patterns of HBV-D and HBV-A and different levels of monophyletic clustering in relation to the regions of prevalence of each genotype.
dc.relation.ispartofeLife
dc.titleUnravelling the history of hepatitis B virus genotypes A and D infection using a full- genome phylogenetic and phylogeographic approach
elsevier.identifier.doi10.7554/eLife.36709
elsevier.identifier.eid2-s2.0-85053917492
elsevier.identifier.scopusidSCOPUS_ID:85053917492
elsevier.volume7
elsevier.coverdate2018-08-07
elsevier.coverdisplaydate7 August 2018
elsevier.openaccess1
elsevier.openaccessflagtrue
elsevier.aggregationtypeJournal


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