Inotropes and vasopressors in post - Resuscitation care
MetadataShow full item record
The post-resuscitation period should comprise a second, more complex phase of interventions which are likely to influence, significantly, the final outcome. As a critical component of post-resuscitation care, prompt optimisation of hemodynamic status by means of targeted interventions is vital in order to maximize the likelihood of a good outcome. In this setting, prompt administration of fluids and potentially vasopressors and inotropes are common treatment modalities of circulatory support after cardiac arrest. Furthermore, vasoactive agents may be required in the setting of underlying conditions complicating the post-resuscitation condition of the patient. The clinical efficacy of inotropes and vasopressors has been largely investigated through examination of their impact on hemodynamic end points, and clinical practice has been driven in part by expert opinion, extrapolation from animal studies, and physician preference. Careful and frequent monitoring of hemodynamic parameters and other measures, as required, is crucial to ensure optimal outcomes with the use of vasoactive agents. Clearly these agents are all supportive measures to stabilise the patient prior to some form of definitive therapy, and it is important to emphasise that all these pharmacological agents are associated with potentially significant side effects.