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dc.contributor.authorEsposito, Francesco
dc.contributor.authorLim, Chetana
dc.contributor.authorSa Cunha, Antonio
dc.contributor.authorPessaux, Patrick
dc.contributor.authorNavarro, Françis
dc.contributor.authorAzoulay, Daniel
dc.contributor.authorCossé, Cyril
dc.contributor.authorLignier, Delphine
dc.contributor.authorRégimbeau, Jean Marc
dc.contributor.authorBarbieux, Julien P.
dc.contributor.authorLermite, Émilie
dc.contributor.authorHamy, Antoine P.
dc.contributor.authorMauvais, François
dc.contributor.authorLaurent, Christophe
dc.contributor.authorNaasan, Irchid Al
dc.contributor.authorAzoulay, Daniel
dc.contributor.authorSalloum, Chady
dc.contributor.authorCompagnon, Philippe
dc.contributor.authorIdrissi, Mohammed Sbai
dc.contributor.authorMartin, Frédéric
dc.contributor.authorAtger, Jérôme
dc.contributor.authorBaulieux, Jacques
dc.contributor.authorDarnis, Benjamin
dc.contributor.authorMabrut, Jean Yves
dc.contributor.authorKépénékian, Vahan
dc.contributor.authorPérinel, Julie
dc.contributor.authorAdham, Mustapha
dc.contributor.authorGléhen, Olivier J.
dc.contributor.authorRivoire, Michel L.
dc.contributor.authorHardwigsen, Jean
dc.contributor.authorPalen, Anaïs
dc.contributor.authorGrégoire, Émilie
dc.contributor.authorLeTreut, Yves Patrice
dc.contributor.authorDelpéro, Jean Robert
dc.contributor.authorTurrini, Olivier
dc.contributor.authorHerrero, Astrid
dc.contributor.authorPanaro, Fabrizio
dc.contributor.authorAyav, Ahmet
dc.contributor.authorBresler, Laurent
dc.contributor.authorRauch, P.
dc.contributor.authorGuillemin, F.
dc.contributor.authorMarchal, F.
dc.contributor.authorGugenheim, J.
dc.contributor.authorIannelli, A.
dc.contributor.authorBenoist, S.
dc.contributor.authorBrouquet, A.
dc.contributor.authorPocard, M.
dc.contributor.authorDico, R.L.
dc.contributor.authorGayet, B.
dc.contributor.authorFuks, D.
dc.contributor.authorScatton, O
dc.contributor.authorSoubrane, O.
dc.contributor.authorVaillant, J.-C.
dc.contributor.authorPiardi, T.
dc.contributor.authorSommacale, D.
dc.contributor.authorKianmanesh, R.
dc.contributor.authorComy, M.
dc.contributor.authorBachellier, P.
dc.contributor.authorOussoultzoglou, E.
dc.contributor.authorAddeo, Pietro F.
dc.contributor.authorNtourakis, Dimitrios
dc.contributor.authorMutter, D.
dc.contributor.authorMarescaux, J.
dc.contributor.authorRaoux, L.
dc.contributor.authorSuc, B.
dc.contributor.authorMuscari, F.
dc.contributor.authorElhomsy, G.
dc.contributor.authorGelli, M.
dc.contributor.authorCunha, A.S.
dc.contributor.authorAdam, R.
dc.contributor.authorCastaing, D
dc.contributor.authorCherqui, D.
dc.contributor.authorPittau, G.
dc.contributor.authorCiacio, O.
dc.contributor.authorVibert, E.
dc.contributor.authorElias, D.
dc.contributor.authorGoére, D.
dc.contributor.authorVittadello, F.
dc.contributor.authorOn behalf of the French Colorectal Liver Metastases Working Group, Association Francaise de Chirurgie (AFC)
dc.date.accessioned2019-02-28T09:20:12Z
dc.date.available2019-02-28T09:20:12Z
dc.date.issued2018-12-01
dc.identifierSCOPUS_ID:85048565750
dc.identifier.issn03642313
dc.identifier.otherPubMed ID: 29947991
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048565750&origin=inward
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/1904
dc.description.abstractObjectives: Multicenter studies comparing the reverse strategy (RS) with the classical strategy (CS) for the management of stage IVA liver-only colorectal cancer (CCR) are scarce. The aim of this study was to compare long-term survival and recurrence patterns following use of the CS and RS. Method: This retrospective multicenter review collected data from all consecutive patients with stage IVA liver-only CCR who underwent staged resection of CCR and liver metastases (LM) at 24 French hospitals between 2006 and 2013 and were retrospectively analyzed. Patients who underwent simultaneous liver and CCR resection, those with synchronous extrahepatic metastasis, and those who underwent emergent CCR resection were excluded. Overall survival (OS) and recurrence-free survival (RFS) rates and recurrence patterns were investigated before and after propensity score matching (PSM). Results: A total of 653 patients were included: 587 (89.9%) in the CS group and 66 (10.1%) in the RS group. Compared with the CS patients, RS patients were more likely to have rectal cancer (43.9 vs. 24.9%; p = 0.006), larger liver tumor size (52.5 ± 38.6 vs. 39.6 ± 30 mm; p = 0.01), and more positive lymph nodes (62.1 vs. 44.8%; p = 0.009). OS was not different between the two groups (75 vs. 72% at 5 years; p = 0.77), while RFS was worse in the RS group (24 vs. 33% at 5 years; p = 0.01). Time to recurrence at any site (1.8 vs. 2.4 years, p = 0.024) and intrahepatic recurrence (1.7 vs. 2.2 years, p = 0.014) were significantly shorter in the RS group than in the CS group. After PSM (63 patients in each group), no significant difference was found between the two groups in OS (p = 0.35), RFS (p = 0.62), time to recurrence at any site (p = 0.19), or intrahepatic recurrence (p = 0.13). Conclusions: In this study, approximately 10% of patients with CCR and synchronous LM were offered surgery with the RS. Both strategies ensured similar oncological outcomes.
dc.relation.ispartofWorld Journal of Surgery
dc.titlePrimary Tumor Versus Liver-First Approach for Synchronous Colorectal Liver Metastases: An Association Française de Chirurgie (AFC) Multicenter-Based Study with Propensity Score Analysis
elsevier.identifier.doi10.1007/s00268-018-4711-x
elsevier.identifier.eid2-s2.0-85048565750
elsevier.identifier.scopusidSCOPUS_ID:85048565750
elsevier.volume42
elsevier.issue.identifier12
elsevier.coverdate2018-12-01
elsevier.coverdisplaydate1 December 2018
elsevier.openaccess0
elsevier.openaccessflagfalse
elsevier.aggregationtypeJournal


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