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dc.contributor.authorSophocleous, Antonia
dc.contributor.authorBörjesson, Anna E.
dc.contributor.authorSalter, Donald Mcgovern
dc.contributor.authorRalston, Stuart H.
dc.creatorSophocleous, Antonia
dc.date.accessioned2019-02-25T09:18:11Z
dc.date.available2019-02-25T09:18:11Z
dc.date.issued2015-09-01
dc.identifierSCOPUS_ID:84940452817
dc.identifier.issn10634584
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84940452817&origin=inward
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/1876
dc.description.abstractObjective: Cannabinoid receptors and their ligands have been implicated in the regulation of various physiological processes but their role in osteoarthritis has not been investigated. The aim of this study was to evaluate the role of the type 2 cannabinoid receptor (Cnr2) in regulating susceptibility to osteoarthritis in mice. Methods: We analysed the severity of knee osteoarthritis as assessed by the Osteoarthritis Research Society International (OARSI) scoring system in mice with targeted deletion of Cnr2 (Cnr2-/-) and wild type (WT) littermates. Studies were conducted in mice subjected to surgical destabilisation of the medial meniscus (DMM) and in those with spontaneous age-related osteoarthritis (OA). Results: Osteoarthritis was more severe following DMM in the medial compartment of the knee in Cnr2-/- compared with WT mice (mean ± sem score = 4.9 ± 0.5 vs 3.6 ± 0.3; P = 0.017). Treatment of WT mice with the CB2-selective agonist HU308 following DMM reduced the severity of OA in the whole joint (HU308 = 8.4 ± 0.2 vs vehicle = 10.4 ± 0.6; P = 0.007). Spontaneous age related osteoarthritis was also more severe in the medial compartment of the knee in 12-month old Cnr2-/- mice compared with WT (5.6 ± 0.5 vs 3.5 ± 0.3, P = 0.008). Cultured articular chondrocytes from Cnr2-/- mice produced less proteoglycans in vitro than wild type chondrocytes. Conclusion: These studies demonstrate that the Cnr2 pathway plays a role in the pathophysiology of osteoarthritis in mice and shows that pharmacological activation of CB2 has a protective effect. Further studies of the role of cannabinoid receptors in the pathogenesis of osteoarthritis in man are warranted.
dc.relation.ispartofOsteoarthritis and Cartilage
dc.titleThe type 2 cannabinoid receptor regulates susceptibility to osteoarthritis in mice
elsevier.identifier.doi10.1016/j.joca.2015.04.020
elsevier.identifier.eid2-s2.0-84940452817
elsevier.identifier.piiS1063458415011401
elsevier.identifier.scopusidSCOPUS_ID:84940452817
elsevier.volume23
elsevier.issue.identifier9
elsevier.coverdate2015-09-01
elsevier.coverdisplaydate1 September 2015
elsevier.openaccess1
elsevier.openaccessflagtrue
elsevier.aggregationtypeJournal


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