Bone cell-autonomous contribution of type 2 cannabinoid receptor to breast cancer-induced osteolysis
Logan, John G.
Ralston, Stuart H.
Idris, Aymen I.
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Background: CB2 is implicated in bone remodeling and tumor growth. Results: CB2 activation enhances breast cancer-induced bone cell activity and osteolysis via the PI3K/AKT pathway. Conclusion: CB2-selective antagonism has potential efficacy in cancer-associated bone disease. Significance: CB2 activation by phytocannabinoids might be detrimental in breast cancer patients with advanced malignancy.