• Login
    View Item 
    •   Plemochoe Home
    • Articles / Άρθρα
    • School of Medicine
    • Department of Medicine
    • View Item
    •   Plemochoe Home
    • Articles / Άρθρα
    • School of Medicine
    • Department of Medicine
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of PlemochoeCommunities & CollectionsTitlesAuthorsBy Issue DateSubjectsThis CollectionTitlesAuthorsBy Issue DateSubjects

    My Account

    LoginRegister

    Effects of early amiodarone administration during and immediately after cardiopulmonary resuscitation in a swine model

    Thumbnail
    View/Open
    Publisher version (Access full-text PDFOpen Access)
    Publisher version (Check access options)
    Check access options
    Date
    2014-01-01
    Author
    Karlis, G.
    Iacovidou, Nicoletta
    Lelovas, Pavlos P.
    Niforopoulou, Panagiota
    Zacharioudaki, Argyro
    Papalois, Αpostolos E.
    Sunde, Kjetil
    Steen, Petter Andreas
    Xanthos, Theodoros
    Metadata
    Show full item record
    Abstract
    Background Aim of this experimental study was to compare haemodynamic effects and outcome with early administration of amiodarone and adrenaline vs. adrenaline alone in pigs with prolonged ventricular fibrillation (VF). Methods After 8 min of untreated VF arrest, bolus doses were administered of adrenaline (0.02 mg/kg) and either amiodarone (5 mg/kg) or saline (n = 8 per group) after randomisation. Cardiopulmonary resuscitation (CPR) was commenced immediately after drug administration, and defibrillation was attempted 2 min later. CPR was resumed for another 2 min after each defibrillation attempt, and the same dose of adrenaline was given every 4th minute during CPR. Haemodynamic monitoring and mechanical ventilation continued for 6 h after return of spontaneous circulation (ROSC), and the pigs were euthanised at 48 h. Researchers were blinded for drug groups throughout the study. Results There was no difference in rates of ROSC and 48-h survival with amiodarone vs. saline (5/8 vs. 7/8 and 0/8 vs. 3/8, respectively). Diastolic aortic pressure and coronary perfusion pressure were significantly lower with amiodarone during CPR and 1 min after ROSC (P < 0.05). The number of electric shocks required for terminating VF, time to ROSC and adrenaline dose were significantly higher with amiodarone (P < 0.01). The incidence of post-resuscitation tachyarrhythmias tended to be higher in the saline group (P = 0.081). Conclusion Early administration of amiodarone did not improve ROSC or 48-h survival rates, and was associated with worse haemodynamics in this swine model of cardiac arrest.
    URI
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84890547452&origin=inward
    https://repo.euc.ac.cy/handle/123456789/1602
    DOI
    10.1111/aas.12226
    Collections
    • Department of Medicine

    entitlement

    Contact us

    Tel: +357 22 713000
    Fax: +357 22 662051
    Use contact form

    Find us

    European University Cyprus
    6, Diogenis Str., Engomi,
    P.O. Box: 22006, 1516 Nicosia-Cyprus
    View location map

    Connect with us

    Send your request to us

    Request Info
     
    • Contact us
    • Find us
    • Connect with us
    • Request Info
    © 2017 European University Cyprus, All Rights Reserved