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dc.contributor.authorPantazopoulos, Charalampos
dc.contributor.authorIacovidou, Nicoletta
dc.contributor.authorKouskouni, Evangelia E.
dc.contributor.authorPliatsika, Paraskevi
dc.contributor.authorPapalois, Αpostolos E.
dc.contributor.authorKaparos, George I.
dc.contributor.authorBarouxis, Dimitrios
dc.contributor.authorVasileiou, Panagiotis V.S.
dc.contributor.authorLelovas, Pavlos P.
dc.contributor.authorKotsilianou, Olympia
dc.contributor.authorPantazopoulos, Ioannis N.
dc.contributor.authorGkiokas, Georgios
dc.contributor.authorGarosa, Clara
dc.contributor.authorFaá, Gavino
dc.contributor.authorXanthos, Theodoros
dc.creatorPantazopoulos, Charalampos
dc.date.accessioned2019-01-15T12:44:12Z
dc.date.available2019-01-15T12:44:12Z
dc.date.issued2016-01-01
dc.identifierSCOPUS_ID:84994682721
dc.identifier.issn23146133
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84994682721&origin=inward
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/1528
dc.description.abstractPurpose. To investigate the effect of EPO administration on postresuscitation renal function. Methods. Twenty-four female Landrace/Large-White piglets aged 10-15 weeks with average weight of 19±2 kg were randomly assigned to 2 different groups of 12 subjects each. After the end of an 8-minute ventricular fibrillation, the control group (Group C) received saline as placebo, whereas the EPO group (Group E) received EPO 5000 U/kg. The animals were resuscitated according to the 2010 European Resuscitation Council Guidelines for Resuscitation. Results. Five animals (41.67%) from Group C and 11 animals (91.67%) from Group E achieved ROSC (p=0.027). Eight animals (66.67%, 5 surviving and 3 nonsurviving) from Group C suffered severe kidney damage or AKI compared to animals from Group E, in which none of the swine had evidence of severe kidney damage or AKI (p=0.001). There was a statistically significant difference in all tested biochemical markers between the two groups, as well as a positive correlation of creatinine with NGAL, L-FABP, and IL-18 (summed mean values' p=0.049, 0.01, and 0.004, resp.). Conclusions. Administration of EPO protected swine from postresuscitation acute kidney injury.
dc.relation.ispartofBioMed Research International
dc.titleEffect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation
elsevier.identifier.doi10.1155/2016/3567275
elsevier.identifier.eid2-s2.0-84994682721
elsevier.identifier.scopusidSCOPUS_ID:84994682721
elsevier.volume2016
elsevier.coverdate2016-01-01
elsevier.coverdisplaydate2016
elsevier.openaccess1
elsevier.openaccessflagtrue
elsevier.aggregationtypeJournal


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