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dc.contributor.authorPetta, Vasiliki
dc.contributor.authorPerlikos, Fotis
dc.contributor.authorLoukides, Stelios
dc.contributor.authorBakakos, Petros
dc.contributor.authorChalkias, Athanasios F.
dc.contributor.authorIacovidou, Nicoletta
dc.contributor.authorXanthos, Theodoros
dc.contributor.authorTsekoura, Dorothea K.
dc.contributor.authorHillas, Georgios
dc.creatorPetta, Vasiliki
dc.date.accessioned2019-01-14T12:45:49Z
dc.date.available2019-01-14T12:45:49Z
dc.date.issued2017-11-01
dc.identifierSCOPUS_ID:85028345878
dc.identifier.issn13824147
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85028345878&origin=inward
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/1510
dc.description.abstractChronic obstructive pulmonary disease (COPD) is a major health problem worldwide, with co-morbidities contributing to the overall severity and mortality of the disease. The incidence and prevalence of cardiovascular disease among COPD patients are high. Both disorders often co-exist, mainly due to smoking, but they also share common underlying risk factors, such as aging and low-grade systemic inflammation. The therapeutic approach is based on agents, whose pharmacological properties are completely opposed. Beta2-agonists remain the cornerstone of COPD treatment due to their limited cardiac adverse effects. On the other hand, beta-blockers are administered in COPD patients with cardiovascular disease, but despite their proven cardiac benefits, they remain underused. There is still a trend among physicians over underprescription of these drugs in patients with heart failure and COPD due to bronchoconstriction. Therefore, cardioselective beta-blockers are preferred, and recent meta-analyses have shown reduced rates in mortality and exacerbations in COPD patients treated with beta-blockers.
dc.relation.ispartofHeart Failure Reviews
dc.titleTherapeutic effects of the combination of inhaled beta2-agonists and beta-blockers in COPD patients with cardiovascular disease
elsevier.identifier.doi10.1007/s10741-017-9646-z
elsevier.identifier.eid2-s2.0-85028345878
elsevier.identifier.scopusidSCOPUS_ID:85028345878
elsevier.volume22
elsevier.issue.identifier6
elsevier.coverdate2017-11-01
elsevier.coverdisplaydate1 November 2017
elsevier.openaccess0
elsevier.openaccessflagfalse
elsevier.aggregationtypeJournal


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