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dc.contributor.authorHadjipanayis, Adamos
dc.contributor.authorEfstathiou, Elisavet
dc.contributor.authorTheophilou, Leda
dc.contributor.authorChrousos, George Panagiotis
dc.creatorHadjipanayis, Adamos
dc.date.accessioned2019-01-08T10:12:44Z
dc.date.available2019-01-08T10:12:44Z
dc.date.issued2017-01-01
dc.identifierSCOPUS_ID:85034418268
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85034418268&origin=inward
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/1435
dc.description.abstractA 12.6-year-old girl presented with a 2-month history of headache, recurrent vomiting and 5 kg weight loss. She had been receiving recombinant human growth hormone (rhGH) replacement therapy at a dose of 0.035 mg/kg for the past 10 months, due to short stature. Investigations before initiating rhGH, including brain MRI, had been normal. Physical examination revealed a nystagmus and a mildly elevated arterial blood pressure. Brain MRI revealed a lesion in the posterior aspect of the medulla oblongata, adjacent to the foramen of Magendie. rhGH therapy was discontinued, followed by a gradual resolution of the symptoms. At follow-up 3 months later, she was asymptomatic and physical examination was unremarkable. A subsequent repeat brain MRI showed complete resolution of the lesion, supporting the diagnosis of a variant of reversible posterior leucoencephalopathy syndrome. This is the first case report of a reversible brain lesion linked to rhGH replacement therapy.
dc.relation.ispartofBMJ Case Reports
dc.titleReversible brain lesion following growth hormone replacement therapy in an adolescent
elsevier.identifier.doi10.1136/bcr-2017-221885
elsevier.identifier.eid2-s2.0-85034418268
elsevier.identifier.scopusidSCOPUS_ID:85034418268
elsevier.volume2017
elsevier.coverdate2017-01-01
elsevier.coverdisplaydate2017
elsevier.openaccess0
elsevier.openaccessflagfalse
elsevier.aggregationtypeJournal


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