Browsing School of Sciences by Title
Now showing items 1-20 of 610
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1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) Inhibitors
(2018-01-01)We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4 ... -
1-D coordination polymers consisting of a high-spin Mn17 octahedral unit
(2009-06-22)The reaction of [Mn(O2CMe)2] · 4H2O with pdH2 (1,3-propanediol) or mpdH2 (2-methyl-1,3-propanediol) in the presence of NaN3 in MeCN/py (py = pyridine) results in the formation of two new one-dimensional coordination polymers ... -
2,4-Dioxa-λ-6-thiatetracyclo-[5.3.1.15,9. 01,5]dodecane-3,3-dione
(2012-06-01)The crystal structure of the title compound, C9H 12O4S, was determined in order to investigate the effect of the eclipsed O atoms on the bond length of the vicinal quaternary C atoms. The two quaternary C atoms of the ... -
2,9-Diiodo-hexa-cyclo-[9.3.1.12,6.14,8.1 9,13.01,8]octa-deca-ne
(2012-08-01)The title compound, C18H24I2, has an adamantanoid structure with tetra-hedral cages having four C atoms lying on the same plane [(I-)C-C-C-C(-I) torsion angle = 0°]. The plane is extended by the two I atoms, each having a ... -
3,5-bis[5-(Thiazol-2-yl)thien-2-yl]-4h-1,2,6-thiadiazin-4-one
(2019-03-01)Stille coupling of 3,5-bis(5-bromothien-2-yl)-4H-1,2,6-thiadiazin-4-one (10) with 2-(tri-n-butylstannyl)thiazole and Pd(Ph 3 P) 2 Cl 2 in PhMe, at ca. 110 ◦ C, for 2 h, gave 3,5-bis[5-(thiazol-2-yl)thien-2-yl]-4H-1,2,6-t ... -
3-chloro-5-(3-n-hexylthien-2-yl)-4H-1,2,6-thiadiazin-4-one
(2019-03-01)Stille coupling of 5-chloro-4-oxo-4H-1,2,6-thiadiazin-3-yl trifluoromethanesulfonate (7) with tributyl(3-n-hexylthien-2-yl)stannane and Pd(Ph 3 P) 2 Cl 2 in PhMe at ca. 20 ◦ C, for 24 h gave 3-chloro-5-(3-n-hexylthien-2- ... -
A 5D computational phantom for pharmacokinetic simulation studies in dynamic emission tomography
(2014-01-01)Introduction: Dynamic image acquisition protocols are increasingly used in emission tomography for drug development and clinical research. As such, there is a need for computational phantoms to accurately describe both the ... -
A comparison between experienced and inexperienced video game players’ perceptions
(2013-12-01)In this article we examine the relationship between usability, hedonic attributes and general appeal of two types of video games, first-person shooters, and massively multi-player online role playing games. Through the use ... -
A continuous link between the disk and half-plane cases of Grace's theorem
(2015-01-01)We obtain a continuous link between the disk and half-plane cases of Grace's theorem and new, non-circular zero domains that stay invariant under the Schur–Szegő convolution. -
A controlled clinical pilot trial to study the effectiveness of ice as a supplement to the exercise programme for the management of lateral elbow tendinopathy
(2006-01-01)Background: The use of ice as a supplement to an exercise programme has been recommended for the management of lateral elbow tendinopathy (LET). No studies have examined its effectiveness. Objectives: To investigate whether ... -
A Decentralized Approach for Self-Coexistence among Heterogeneous Networks in TVWS
(2018-02-01)This paper focuses on coexistence and self-coexistence challenges between secondary heterogeneous wireless networks/users sharing TV Whitespace spectrum. The coexistence problems arise from having several primary and ... -
A diet rich in monounsaturated fatty acids improves the lipid profile of mice previously on a diet rich in saturated fatty acids
(2011-11-01)This study investigated whether switching from a diet rich in saturated fatty acids (SAFAs) to a diet rich in monounsaturated fatty acids (MUFAs) or to one with equal amounts of MUFAs-SAFAs favorably affects the lipid ... -
A dust-enshrouded tidal disruption event with a resolved radio jet in a galaxy merger
(2018-08-03)Tidal disruption events (TDEs) are transient flares produced when a star is ripped apart by the gravitational field of a supermassive black hole (SMBH). We have observed a transient source in the western nucleus of the ... -
A family of 3D coordination polymers composed of Mn19 magnetic units
(2006-11-27)(Figure Presented) Singles networks: The use of 1,3-propanediol and of 2-methyl-1,3-propanediol in manganese carboxylate chemistry leads to two new 3D coordination polymers with an unprecedented Mn19 repeating unit. The ... -
A far-infrared survey at the North Galactic Pole - I. Nearby star-forming galaxies and effect of confused sources on source counts
(2010-01-01)We present follow-up observations of the far-infrared (FIR) sources at 90, 150 and 180 μm detected as part of the ISOPHOT EBL project, which has recently measured the absolute surface brightness of the cosmic infrared ... -
A graph-theoretic network security game
(2008-11-01)Consider a network vulnerable to viral infection, where the security software can guarantee safety only to a limited part of it. We model this practical network scenario as a non-cooperative multi-player game on a graph, ... -
A hierarchical clustering methodology based on genetic programming for the solution of simple cell-formation problems
(2001-01-10)The problem of identifying machine cells and corresponding part families in cellular manufacturing has been extensively researched over the last thirty years. However, the complexity of the problem and the considerable ... -
A large [Mn10Na]4 loop of four linked Mn10 loops
(2007-05-14)A large [Mn10Na]4 loop-of-loops aggregate was prepared from the use of 1,3-propanediol (pdH2) in manganese carboxylate chemistry. It is constructed from four [Mn10(μ 3-O)2(O2CMe)13(pd) 6(py)2]- loops linked through Na+ ... -
A Microporous Co(II)-Based 3-D Metal Organic Framework Built from Magnetic Infinite Rod-Shaped Secondary Building Units
(2019-10-17)Invited for the cover of this issue is Anastasios Tasiopoulos from the University of Cyprus. The cover image shows photos from the southwestern Cyclades island group of the Aegean Sea, which contain a wealth of minerals ... -
A microporous Co2+ metal organic framework with single-crystal to single-crystal transformation properties and high CO2 uptake
(2015-01-07)The synthesis and characterization of {[Co9(INA)18(H2O)6]·11DMF·15H2O}∞ (Co9-INA·11DMF·15H2O) (INA- = the anion of isonicotinic acid) is reported. It exhibits a rigid 3D-porous structure with a Co9 repeating unit consisting ...