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dc.contributor.authorGkretsi, Vasiliki
dc.contributor.authorBogdanos, Dimitrios P.
dc.creatorGkretsi, Vasiliki
dc.date.accessioned2018-11-26T13:59:50Z
dc.date.available2018-11-26T13:59:50Z
dc.date.issued2015-01-01
dc.identifierSCOPUS_ID:84925003100
dc.identifier.issn02507005
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84925003100&origin=inward
dc.identifier.urihttps://repo.euc.ac.cy/handle/123456789/1026
dc.description.abstractBackground/Aim: Extracellular matrix (ECM) is of great significance for homeostasis in the liver. In fact, one of the stages leading to hepatocellular carcinoma (HCC) includes accumulation of excess ECM. Ras Suppressor-1 (RSU-1) is localized in the cell-ECM adhesions but its role in HCC is unexplored. Materials and Methods: We investigated the expression and role of RSU-1 in two HCC cell lines that differ in aggressiveness; non-invasive Alexander cells and highly invasive HepG2 cells. Results: Our results showed that RSU-1 expression is elevated in HepG2 cells both at the mRNA and protein level, while its silencing leads to increased cell proliferation in both cell lines. Interestingly, RSU-1 depletion from highly invasive HepG2 cells reduces cell adhesion and invasion. Conclusion: This is the first study to provide in vitro evidence for the involvement of RSU-1 in HCC cell invasive behavior.
dc.relation.ispartofAnticancer Research
dc.titleElimination of ras suppressor-1 from hepatocellular carcinoma cells hinders their in vitro metastatic properties
elsevier.identifier.eid2-s2.0-84925003100
elsevier.identifier.scopusidSCOPUS_ID:84925003100
elsevier.volume35
elsevier.issue.identifier3
elsevier.coverdate2015-01-01
elsevier.coverdisplaydate1 March 2015
elsevier.openaccess0
elsevier.openaccessflagfalse
elsevier.aggregationtypeJournal


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