Now showing items 1-7 of 7

    • Activin a signaling regulates IL13Rα2 expression to promote breast cancer metastasis 

      Kalli, Maria; Mpekris, Fotios; Wong, Chen Khuan; Panagi, Myrofora; Ozturk, Sait; Thiagalingam, Sam; Stylianopoulos, Triantafyllos; Papageorgis, Panagiotis (2019-01-01)
      Metastatic dissemination of cancer cells to distal organs is the major cause of death for patients suffering from the aggressive basal-like breast cancer (BLBC) subtype. Recently, we have shown that interleukin 13 receptor ...
    • Breast cancer 

      Lambert, Arthur W.; Ozturk, Sait; Wong, Chen Khuan; Papageorgis, Panagiotis; Thiagalingam, Sam (2015-01-01)
      The notion that breast cancer is not a single disease but many – that there is considerable heterogeneity among different tumors – is not new, having been observed by physicians for decades. But with the advent of powerful ...
    • Cancer metastasis 

      Ozturk, Sait; Lambert, Arthur W.; Wong, Chen Khuan; Papageorgis, Panagiotis; Thiagalingam, Sam (2015-01-01)
      Metastasis is the cause of almost all cancer-related deaths. It is an extremely complex, multistep process defined as the spreading of cancer cells from their primary site to distant tissues. Once metastasis occurs it ...
    • MicroRNA-4417 is a tumor suppressor and prognostic biomarker for triple-negative breast cancer 

      Wong, Chen Khuan; Gromisch, Christopher; Ozturk, Sait; Papageorgis, Panagiotis; Abdolmaleky, Hamid Mostafavi; Reinhard, Björn M.; Thiagalingam, Arunthathi; Thiagalingam, Sam (2019-01-01)
      Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer with poor prognosis due to lack of druggable targets such as hormone and growth factor receptors. Therefore, identification of targetable ...
    • SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis 

      Ozturk, Sait; Papageorgis, Panagiotis; Wong, Chen Khuan; Lambert, Arthur W.; Abdolmaleky, Hamid Mostafavi; Thiagalingam, Arunthathi; Cohen, Herbert T.; Thiagalingam, Sam (2016-01-19)
      Metastatic dissemination of breast cancer cells represents a significant clinical obstacle to curative therapy. The loss of function of metastasis suppressor genes is a major rate-limiting step in breast cancer progression ...
    • Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis 

      Papageorgis, Panagiotis; Ozturk, Sait; Lambert, Arthur W.; Neophytou, Constantinos M.; Tzatsos, Alexandros; Wong, Chen Khuan; Thiagalingam, Sam; Constantinou, Andreas I. (2015-07-25)
      Introduction: Basal-like breast cancer (BLBC) is an aggressive subtype often characterized by distant metastasis, poor patient prognosis, and limited treatment options. Therefore, the discovery of alternative targets to ...
    • Tumor cell-derived periostin regulates cytokines that maintain breast cancer stem cells 

      Lambert, Arthur W.; Wong, Chen Khuan; Ozturk, Sait; Papageorgis, Panagiotis; Raghunathan, Rekha; Alekseyev, Yuriy O.; Gower, Adam C.; Reinhard, Björn M.; Abdolmaleky, Hamid Mostafavi; Thiagalingam, Sam (2016-01-01)
      Basal-like breast cancer (BLBC) is an aggressive subtype of breast cancer which is often enriched with cancer stem cells (CSC), but the underlying molecular basis for this connection remains elusive. We hypothesized that ...