Now showing items 1-10 of 10

    • Aberrant activation of γ-catenin promotes genomic instability and oncogenic effects during tumor progression 

      Pan, Hongjie; Gao, Fangming; Papageorgis, Panagiotis; Abdolmaleky, Hamid Mostafavi; Faller, Douglas V.; Thiagalingam, Sam (2007-01-01)
      γ-catenin (plakoglobin) exists in cells either as a component of adherens junctions, along with β-catenin and α-catenin, or in association with desmoplakin in desmosomes, which are in turn coupled to the cytoskeleton linking ...
    • Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder 

      Abdolmaleky, Hamid Mostafavi; Yaqubi, Sahab; Papageorgis, Panagiotis; Lambert, Arthur W.; Ozturk, Sait; Sivaraman, Vadivelu; Thiagalingam, Sam (2011-07-01)
      ntroduction: HTR2A gene has been the subject of numerous studies in psychiatric genetics because LSD, which resembles serotonin causes psychosis and atypical antipsychotic drugs target the HTR2A receptor. However, evidence ...
    • hBub1 deficiency triggers a novel p53 mediated early apoptotic checkpoint pathway in mitotic spindle damaged cells 

      Gao, Fangming; Ponte, Jose F.; Papageorgis, Panagiotis; Levy, Mary; Ozturk, Sait; Lambert, Arthur W.; Pan, Hongjie; Chinnappan, Dharmaraj; Cheng, Kuanghung; Thiagalingam, Arunthathi; Abdolmaleky, Hamid Mostafavi; Thiagalingam, Sam (2009-04-01)
      It has been universally believed that spindle assembly checkpoint (SAC) proteins which include the kinetochore proteins are involved in monitoring the faithful segregation of sister chromatids during cell division and hence ...
    • hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation 

      Gao, Fangming; Ponte, Jose F.; Levy, Mary; Papageorgis, Panagiotis; Cook, Nathaniel M.; Ozturk, Sait; Lambert, Arthur W.; Thiagalingam, Arunthathi; Abdolmaleky, Hamid Mostafavi; Sullivan, Beth A.; Thiagalingam, Sam (2009-04-01)
      Our previous studies showed that the depletion of the outer kinetochore protein hBub1 upon activation of spindle assembly checkpoint (SAC) primarily triggers early cell death mediated by p53 rather than aneuploidy. Here, ...
    • Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder 

      Abdolmaleky, Hamid Mostafavi; Cheng, Kuanghung; Faraone, Stephen V.; Wilcox, Marsha A.; Glatt, Stephen J.; Gao, Fangming; Smith, Cassandra L.; Shafa, Rahim; Aeali, Batol; Carnevale, Julie; Pan, Hongjie; Papageorgis, Panagiotis; Ponte, Jose F.; Sivaraman, Vadivelu; Tsuang, Ming TSO; Thiagalingam, Sam (2006-11-01)
      The variability in phenotypic presentations and the lack of consistency of genetic associations in mental illnesses remain a major challenge in molecular psychiatry. Recently, it has become increasingly clear that altered ...
    • MicroRNA-4417 is a tumor suppressor and prognostic biomarker for triple-negative breast cancer 

      Wong, Chen Khuan; Gromisch, Christopher; Ozturk, Sait; Papageorgis, Panagiotis; Abdolmaleky, Hamid Mostafavi; Reinhard, Björn M.; Thiagalingam, Arunthathi; Thiagalingam, Sam (2019-01-01)
      Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer with poor prognosis due to lack of druggable targets such as hormone and growth factor receptors. Therefore, identification of targetable ...
    • SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis 

      Ozturk, Sait; Papageorgis, Panagiotis; Wong, Chen Khuan; Lambert, Arthur W.; Abdolmaleky, Hamid Mostafavi; Thiagalingam, Arunthathi; Cohen, Herbert T.; Thiagalingam, Sam (2016-01-19)
      Metastatic dissemination of breast cancer cells represents a significant clinical obstacle to curative therapy. The loss of function of metastasis suppressor genes is a major rate-limiting step in breast cancer progression ...
    • Smad signaling is required to maintain epigenetic silencing during breast cancer progression 

      Papageorgis, Panagiotis; Lambert, Arthur W.; Ozturk, Sait; Gao, Fangming; Pan, Hongjie; Manne, Upender; Alekseyev, Yuriy O.; Thiagalingam, Arunthathi; Abdolmaleky, Hamid Mostafavi; Lenburg, Marc E.; Thiagalingam, Sam (2010-02-01)
      Breast cancer progression is associated with aberrant DNA methylation and expression of genes that control the epithelial-mesenchymal transition (EMT), a critical step in malignant conversion. Although the genes affected ...
    • Smad4 inactivation promotes malignancy and drug resistance of colon cancer 

      Papageorgis, Panagiotis; Cheng, Kuanghung; Ozturk, Sait; Gong, Yi; Lambert, Arthur W.; Abdolmaleky, Hamid Mostafavi; Zhou, Jinrong; Thiagalingam, Sam (2011-02-01)
      SMAD4 is localized to chromosome 18q21, a frequent site for loss of heterozygosity in advanced stage colon cancers. Although Smad4 is regarded as a signaling mediator of the TGFβ signaling pathway, its role as a major ...
    • Tumor cell-derived periostin regulates cytokines that maintain breast cancer stem cells 

      Lambert, Arthur W.; Wong, Chen Khuan; Ozturk, Sait; Papageorgis, Panagiotis; Raghunathan, Rekha; Alekseyev, Yuriy O.; Gower, Adam C.; Reinhard, Björn M.; Abdolmaleky, Hamid Mostafavi; Thiagalingam, Sam (2016-01-01)
      Basal-like breast cancer (BLBC) is an aggressive subtype of breast cancer which is often enriched with cancer stem cells (CSC), but the underlying molecular basis for this connection remains elusive. We hypothesized that ...